Fibromyalgia is a mysterious chronic pain disorder that is difficult to treat and its causes are also still largely in the dark

A study conducted by the team at the Clinic for Psychosomatic Medicine and Psychotherapy at Ruhr University Bochum, Germany, provides evidence that certain brain areas involved in processing pain don’t function normally in fibromyalgia patients.

In healthy people, they ensure that pain that we can control is easier to bear. The study found that these brain areas showed altered activity in patients with fibromyalgia. The research team was headed by Professor Martin Diers.

The degree to which we experience pain and the restriction caused by it depend largely on how we perceive it.

If we have the feeling that we can control the pain and shut it down ourselves, for example, we will tolerate it better than if we feel at its mercy.

Lead author Benjamin Mosch said: “For people with chronic pain, the inability to control repeated attacks of pain is one of the most significant causes of impaired quality of life, and yet, the underlying neural mechanisms have so far mainly been studied in healthy controls.”



Heat pain


In the current study, the team compared two female cohorts: 21 healthy participants and 23 fibromyalgia patients.

Both groups were exposed to heat pain while their brain activities were monitored by functional magnetic resonance imaging.

In one experimental run, the participants were able to stop the pain stimulus themselves. In another run, a computer controlled the start and end of the stimulus.

Diers explained: “We kept the duration of the stimuli terminated by the computer the same on average as the stimuli terminated by the test subjects.”

When women in the healthy control group were able to terminate the pain stimulus themselves, a number of mainly frontal brain areas were activated that seem to play an important role in modulating pain.

This observation is consistent with previous studies involving healthy subjects.

Diers added: “Interestingly, however, we didn’t detect any such activations in our patient group.

“This can serve as evidence for impaired pain processing among patients with fibromyalgia.

“It indicates that the cognitive resources for dealing with acute pain are impaired in these patients.”




Fibromyalgia was added to the World Health Organization’s catalogue in 1994.

An estimated 2% of the German population is affected, 90% of them are women.

The disorder is characterised by recurring pain as well as various other symptoms, including sleep disturbances, depressive moods, chronic fatigue and digestive problems.

On average, it takes 16 years before a diagnosis is made.

The research is published in NeuroImage: Clinical.

Image: The so-called thermode can administer heat stimuli, which the test persons could either end themselves or which the computer controlled. © Benjamin Mosch.

Research Aether / Health Uncovered